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Solid Lipid Nanoparticles: A Lipid Based Drug Delivery

Volume No : Volume: 02 Issue : 8 Year : 2014 Page No: 365-376

Authors : Sarika Nikam, Mayura Chavan, Padmini. H. Sharma

Abstract :

Solid Lipid Nanoparticles is one of the new types of colloidal drug carrier system. SLN consist spherical particles of nanometer range dispersed in water or aqueous surfactant solution. Due to biodegradable and bioacceptable nature of SLN these are less toxic than polymeric nanoparticles and it also overcomes some disadvantage of traditional colloidal drug carrier system. Preparation methods of SLN like hot & cold homogenisation, ultrasonication, emulsification, supercritical fluid technique are described. Aspect of solid lipid nanoparticles their uptake, route of administration, applications, list of different lipid, surfactant are incorporated. Characterisation of SLN by appropriate method like photon correlation spectroscopy, scanning electron microscopy, differential scanning colorimetry is highlighted.

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