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Formulation and evaluation of diclofenac sodium effervescent tablet

Volume No : Volume: 02 Issue : 7 Year : 2014 Page No: 350-358

Authors : Bharat W. Tekade, Umesh T. Jadhao, Vinod M. Thakare, Leena R. Bhortake

Abstract :

Ten different formulations were prepared (F1-F10) that contain citric acid, sodium bicarbonate and sodium carbonate, PVP K 30, PEG 6000, different flavors by wet granulation method with an objective to minimize the side effects of diclofenac sodium on gastric mucosa by preparing the diclofenac tablet using effervescent techniques. The prepared tablets were evaluated for various pre and post compression characteristics as per official and non- officials procedures. Among all the formulations, batch F10 showed that maximum drug release upto 94.86 % within 3 min. Selected as optimized batch kept for accelerated stability study for 90 days. The result of stability study indicates no significant difference between the parameters tested before and after stability studies. FTIR Spectroscopy of formulation F10 did not show any additional peaks for new functional groups indicating no chemical interaction between drug and excipient used in formulation.

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