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Superdisintegrant efficiency in acid tolerance in enteric coated diclofenac sodium tablets

Volume No : Volume: 02 Issue : 7 Year : 2014 Page No: 350-368

Authors : Nwoko Valentine Eziokwu

Abstract :

Superdisintegrants are frequently used in tablet core formulations intended for enteric coating. The influence of superdisintegrant types and levels on the performance of enteric coated tablet formulations has been investigated. The core formulation markedly influences the functionality of a gastric resistant coat. A high water uptake of the core leads to increase in volume which in turn causes crack in the functional coat followed by increase in drug release. The application of an instant release sub-coat is appropriate for to prevent early drug release. This delays water permeation allowing MAE to take up water which acts as additional plasticizers.

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