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Experimental Animal Models of Parkinson’s Disease: A Neurotoxin Overview

Volume No : Volume: 01 Issue : 4 Year : 2013 Page No: 265-277

Authors : Sabeena Sharma, Sumita Manhas, Ashwani Kumar, Vijay Pal singh, Vishavdeep Sharma, Shivreet Kaur, Samardeep Singh, Priyanka Chhabra, Vijay Kumar, Sorabh Sharma, Kushal Kumar, Rahul Deshmukh

Abstract :

Parkinson’s disease is a neurodegenerative disorder occurs due to selective degeneration of dopaminergic neurons in substantia nigra pars compacta and nigrostriatal pathways. Neurotoxins causing selective striatal/nigral degeneration of dopaminergic neurons have led us to understand the pathological aspects of Parkinson’s disease. Although the current understanding of PD pathology has significantly increased, however, the exact pathogenic mechanisms involved in PD remained elusive and so the treatments. The present review is aimed to critically discuss the neurotoxic models of PD and to provide an updated summary of the main characteristics of these model systems along with their advantages and limitations of what we believe to be the most popular PD animal models.

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