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Formulation and evaluation of bilayered tablets of losartan potassium

Volume No : Volume: 02 Issue : 5 Year : 2014 Page No: 312-320

Authors : K. Ramya Reddy and N. Srinivas

Abstract :

Bi-layer tablet is suitable for sequential release of two drugs in combination and also for single drug as immediate dose and maintenance dose. Losartan Potassium is an anti hypertensive drug acts by antagonizing Angiotensine II receptors. The aim of present study is to prepare bilayer tablets of Losartan Potassium with an immediate release and a sustained release layer. The immediate release layer was prepared using super disintegrant sodium starch glycolate and sustained release layer is formulated with different polymers such as xanthum gum, gum karaya and hydroxy propyl methyl cellulose K4M, individually in different concentrations and in combinations. The preformulation studies of formulations showed good flow properties and feasibility for direct compression. The compressed bilayered tablets were evaluated for hardness, friability, weight variation, drug content uniformity and in vitro drug release. Formulation contained combination of xanthum gum and gum karaya was optimized which showed prolonged release of Losartan Potassium for about 24 hrs. No significant change either in physical appearance, drug content or in dissolution pattern was observed after storing at 40°C/75% relative humidity (RH) for 1 month in respect of the optimized formulation. FTIR studies revealed no chemical interaction between drug and adjuvant as well as adjuvant and adjuvant which indicates the stability of drug in tablets.

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