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The potential role of transient receptor potential vanilloid 1 receptor in vincristine induced neuropathic pain

Volume No : Volume: 01 Issue : 4 Year : 2013 Page No: 277-285

Authors : Thanaa A. El-Masry, Magda E. El Sayaad, Karima I. El Desoky, Wafaa M. Fouda

Abstract :

Background :Vincristine is one of the most common chemotherapeutic drugs used to treat various types of malignancies Its major dose-limiting side effect is neurotoxicity that requires discontinuation of treatment. Methods : in rat model of vincristine induced neuropathic pain we tried to investigate the potential analgesic effect of SB-366791 ,the trpv1 receptor antagonist, on vincristine induced pain via behavioral tests as tail immersion & hot plate tests , also via measuring the level of some pain mediator and histopathological examination of sciatic nerve. Results : We found that vincristine induce thermal hyperalgesia assessed by behavioral and biochemical testes, whereas SB-366791 showed improvement in thermal hyperalgesia induced by vincristine and showed significant decrease in pain mediators like serum tumor necrosis factor alpha level and spinal nitric oxide content and also improvement in histopathological examination of sciatic nerve fiber. Conclusion: the result indicates that trpv1 receptor may have a potential role in vincristine induced neuropathic pain.

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