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Formulation and evaluation of sustained release glipizide  tablet  using different polymers

Volume No : (2017) Volume: 05 Issue : 27 Year : 2017 Page No: 159-165

Authors : Mahesh T Gaikwad , Bhagyashri S. Kanadje , Sachin Dilip Pawar

Abstract :

The glipizide sustained release (SR) tablet was prepared using different hydrophilic polymers such as hydroxypropyl methylcellulose (HPMC) K4M, HPMC K100M, and ethyl cellulose in various proportions. Design Expert software used for formulation of glipizide SR tablet. The SR tablet was prepared by direct compression method. The prepared SR tablets were subjected to thickness, friability, weight variation test, drug content, hardness, and in vitro release studies. The drug excipients compatibility was evaluated by Fourier transform infrared (FTIR) and differential scanning calorimetry (DSC) studies. In vitro dissolution study shows that F6 formulation was 97% releases the drug in a controlled manner for 16 h. The DSC and FTIR studies revealed that there was no interaction between drug and excipients. Stability studies were carried out for optimized formulation according to ICH guidelines. Using different hydrophilic polymers in various proportions to prepare SR tablets of glipizide having prolonged therapeutic effect with enhanced patience compliance.

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