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Experimental investigation of marigold extract: Modulates isoproterenol induced myoardial ischemia in rats

Volume No : (2016) Volume: 04 Issue : 24 Year : 2016 Page No: 743-757

Authors : Sidharth Mehan, Rajesh Dudi, Ravinder Khatri, Sanjeev Kalra

Abstract :

Ischemic heart disease is a major leading cause of morbidity and mortality. Myocardial infarction is a condition where loss of myocytes takes place due to prolonged ischemic condition and adrenergic over activation. High oxidative stress and myocardial inflammation play key role in the pathogenesis of myocardial infarction. In myocardial ischemia, generation of reactive oxygen species (ROS) and decreased level of antioxidant defense mechanism is associated with its main pathophysiology. Experimentally, Isoproterenol-induced myocardial infarction with β-adrenergic sympathetic overactivation. The -adrenergic Gs signalling activation results in the elevation of cAMP through adenyl cyclase activation, leading to phosphorylation of L-type calcium channels and elevation of intracellular calcium concentration, results in ultrastructural changes, alteration of gene transcription and activation of calcium dependent endonuclease (DNase I), causing loss of myocytes through apoptosis. However, in present research, Marigold extract ameliorate the cardio-toxic effect of isoproterenol, significantly prevent the damages induced by isoproterenol on histopathological and biochemical changes in rat model of myocardial infarction. Furthermore, Marigold extract Calendula Officinalis have a high potent anti-oxidant potential. Thereby, this study discuss information gleaned for various herbal drugs suggesting that adding herbs to daily life serve as scrumptious and sensible way to keep heart healthy.

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