Volume No : (2016) Volume: 04 Issue : 24 Year : 2016 Page No: 721-725
Authors : Aijaz A. Sheikh, Sajid R. Sheikh
Abstract :
In modern therapeutics the controlled/sustained release dosage forms have become extremely popular. Development of sustained release injectable has occurred in the past few years. This was brought into existence to prolong the effect of drug at targeted site. This advancement also offers reducing dosing frequency, maximizing the efficacy dose relationship, decreasing adverse side effects and enhancing patient compliance. The Parenteral administration route is the most common and efficient for delivery of active drug substances with poor bio-availability and the drugs with a narrow therapeutic index. But parenteral route offers rapid onset of action with rapid declines of systemic drug level. For the sake of effective treatment it is often desirable to maintain systemic drug levels within the therapeutically effective concentration range for as long as treatment calls for. It requires frequent injection, which ultimately leads to patient discomfort. For this reason, drug delivery system which can reduce total number of injection throughout the effective treatment, improve patient compliance as well as pharmacoeconomic. Parenteral drug delivery with intravenous, subcutaneous or intramuscular injection can gain easy access to systemic circulation with rapid drug absorption. For the sake of effective treatment it is often desirable to maintain systemic drug levels within the therapeutically effective concentration range for as long as treatment calls for. This review focused on the brief discussion on the latest injectable controlled released dosage forms.
Full Text PDF