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Antidepressant activity of “Cissampelos pareria” extract in mice

Volume No : (2016) Volume: 04 Issue : 23 Year : 2016 Page No: 736-740

Authors : P. Venkata Ravikanth, Rama Devi B, Ganji Naveen, K.V.Ramanamurhty

Abstract :

Depression is a wide spread psychiatric disorder affecting around 5% of the population and it is difficult to predict the patient response to any given treatment. The present study aimed at studying the pharmacological activity of Cissampelos pareria leaves that contain bis benzylisoquinoline alkaloids (BIA), tetrandin, bebriberin, and flavons that are known for their anti anxiolytic activity. These alkaloids act by inhibiting mono amino oxidase (MAO), the enzyme responsible for metabolism of monoamine neurotransmitters. The present study was under taken to evaluate the anti depressant activity of “cissampelos pareria” extract in mice at doses of 100 and 200 mg/kg p.o., against standard Imiparamine (10mg/kg) and control (1% gum acacia). Tail suspension test and forced swim test was conducted and duration of immobility was recorded, in both of these tests carried, Cissampelos Pareria (200mg/kg p.o.) produced significant antidepressant activity compared with the standard Imipramine, which was evident from the decreased immobility when extract was used.

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