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Development and evaluation of novel skin lightening preparation

Volume No : (2016) Volume: 04 Issue : 22 Year : 2016 Page No: 196-201

Authors : Ruhi R. Shaikh, Subhash V. Deshmane, Kailash R. Biyani

Abstract :

Skin lightening creams are the products which work on skin by reducing a pigment called melanin in the skin. It also lightens naturally dark skin. In this research article various In-Vitro and In-Vivo studies are conducted for the preparation of skin lightening cream. Base is formulated and various evaluation testing’s of base formulation is done that include pH, Consistency, appearance, spreadability, viscosity and according to these testing’s the one base formulation is selected optimized. Further active ingredients are incorporated in optimized base and five formulations are made, and evaluation testing’s of formulations is done that included In-Vitro study: pH, Consistency, appearance, spreadability, viscosity, total fatty substance content &water content, thermal stability. The one formulation is selected that have very satisfactory results and its further study is done that include Antimicrobial study and Stability study. In-Vivo study is also done that includes: skin irritation test and photographic evaluation. Very satisfactory and desirable results are obtained after all the evaluation studies. Finally a novel skin lightening Preparation was developed.

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