Volume No : (2016) Volume: 04 Issue : 22 Year : 2016 Page No: 189-195
Authors : Biswajit Bhunia, Sajari Biswajit Bhunia, Swati Rawat
Abstract :
Loratadine is a second-generation peripheral histamine H1-receptor blocker used to treat allergies. The designing and formulation is key factor to commercial any product. Quality by Design (QbD) is increasingly becoming an important and widely used technique in pharmaceutical product development. The present work aims to propose control strategy for commercial manufacturing of Loratadine as an ODT. The control strategies including proposal of different parameters including strategies for raw materials, mixing time, speed of impeller and chopper, inlet temperature, screen size and mill speed, blending and lubrication time, and tablet compression.
Full Text PDF