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Formulation and evaluation of colon-specific microbially dissolvable matrix aceclofenac tablets

Volume No : (2015) Volume: 03 Issue : 15 Year : 2015 Page No: 544-553

Authors : Shivam Patel, Nidhi Patel, Smit Chaudhary, Hitesh Jain, Umesh Upadhyay

Abstract :

The aim of the present work was to formulate and evaluate colon specific sustained release matrix tablet of aceclofenac using different concentrations of microbial-dissolvable polysaccharides like xanthan gum, guar gum, pectin, katira gum and sterculia gum. These colon targeted matrix tablets were prepared by wet granulation technique. All combinations of matrix formulation sprepared within the official limits showed the desired physicochemical properties. All the batches of matrix tablets (F1 to F15) were subjected for in vitro dissolution studies in various simulated gastric fluids to target colon-specific drug delivery system. The drug release study results showed good sustained release dissolution profile for formulation F15.

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