Aim and Objective: The proposed methodology was aimed at comparing the five different brandsof pantoprazole (40 mg) to ensure safety, efficacy, accepted quality, and rationality of use to protectpublic health. The comparison was based on some physicochemical properties of drug and otherparameters such as weight variation test, thickness test, hardness test, disintegration test, dissolutiontest, pure drug analysis, ultraviolet (UV) spectrophotometry, assay of brands, and infrared spectroscopy.
Methods Used: Different paracetamol brands were evaluated on the basis of preparation of standardsample, assay of drug, limit of detection, limit of quantification, weight variation test, thickness test,hardness test, disintegration test, dissolution test, pure drug analysis, UV spectrophotometry, assay ofbrands, and infrared spectroscopy.
Results: All brands were evaluated using established proceduresto assess the pharmaceutical quality characteristics. The measured thickness of studied brand tabletsranged from 2.79 mm to 3.49 mm. The disintegration time test indicated that any of the pantoprazolesodium tablet brands did not disintegrate in 0.1 N HCl acidic medium for 2 h but all disintegratedin the time range of 12.43–24.42 min in phosphate buffer.
Conclusion: This study aimed withcomparative in vitro evaluation of different brands of pantoprazole sodium tablets available in differentretail outlets in Addis, Ababa, Ethiopia. All brands were evaluated using established procedures to assessthe pharmaceutical quality characteristics. The study results revealed that all of the tested brands ofthe pantoprazole sodium enteric coated tablet fulfilled the criteria set in the official monograph forin vitro quality control tests.