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Formulation and evaluation of nanosponge gel containing ketoconazole

Volume No : (2021) Volume: 09 Issue : 41 Year : 2021 Page No: 15-24

Authors : Umesh T. Jadhao, Rathod P. Sayali, Dhembre N. Gunesh, Sable D. Shital, Lokhande S. Sneha

Abstract :

Aim: The aim of present work is to successfully formulate, evaluate and optimize nanosponges of ketoconazole drug for its efficient delivery through gel base. Methodology: Nanosponges were prepared using hyper cross-linked β-cyclodextrin method using different concentration of cross-linker. Diphenyl carbonate was used as the cross-linking polymer. Nanosponge formulations were prepared using β-CD:cross-linker ratios of 1:15–1:3.
Results: The prepared nanosponges were evaluated for percentage yield, incorporation efficiency, particle size, drug polymer compatibility, scanning electron microscopy (SEM), and in vitro drug release. SEM studies confirmed their porous structure with number of nanochannels. The Fourier transform infrared spectra showed stable character of ketoconazole in mixture of polymers. Differential Scanning Calorimetry study revealed that drug was involved in complexation with nanosponges. The average particle size of nanoparticles was found to be 78.81 ± 0.20 nm–336.02 ± 0.124 nm. The drug release from nanosponges was found to extend up to 8 h 82–92%. The nanosponges were formulated into gel using Carbopol 940 Batches G1 to G4 and were prepared by incorporating nanosponges equivalent to 6% w/w of ketoconazole in different polymer concentrations, respectively, and evaluated for percent drug content, viscosity study, spreadability study, and in vitro diffusion studies. Drug diffusion from the nanosponge loaded gel formulations was show sustained rate.
Conclusion: A sustained release topical drug delivery of ketoconazole developed as a nanosponge loaded gel offers solubilizing matrix for the drug, served as a local depot for sustained drug release, and provided a rate limiting matrix barrier for modulation of drug release 

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