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Antidiabetic potential of ethanolic leaf extract of Crataeva magna in streptozotocin-induced diabetic model

Volume No : (2021) Volume: 09 Issue : 41 Year : 2021 Page No: 1-7

Authors : Faheem I.P, B. Gopalakrishna, Mohsina F.P, Sarah Priya

Abstract :

Aim: In the present study, the ethanolic leaf extracts of Crataeva magna (ELECM) at various concentrations were prepared and anti-diabetic activity was evaluated. Materials and Methods: Diabetes was induced by single injection of streptozotocin (65 mg/kg, i.p.) and various biochemical parameters were assessed using commercial available kits.

Results: ELECM showed dose-dependent reversal of increase in blood glucose level in diabetic rats. Moreover, ELECM also reversed the abnormal lipid profile in diabetic rats as reflected by decrease level of total cholesterol, triglyceride, very low-density lipoprotein (VLDL), and LDL and increase level of high-density lipoprotein. Moreover, ELECM also showed in vivo antioxidant activity by increasing level of antioxidant enzymes such as reduced glutathione (GSH), sodium dismutase, and catalase along with decreasing oxidant markers such as thiobarbituric acid level. Conclusion: In the light of the above consideration, the results of the study revealed that ELECM showed promising antidiabetic activity in a dose-dependent manner

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