Volume No : (2020) Volume: 08 Issue : 40 Year : 2020 Page No: 121-127
Authors : Tejvir Kaur
Abstract :
The rate-limiting step in oral absorption of Biopharmaceutical Classification System (BCS) Class II poorly water-soluble drugs is the dissolution process; thus, finding a simple and feasible means to improve this aspect is desirable. The most attractive and simplest approach to enhance the dissolution of poorly watersoluble drug is by increasing its solubility and/or available surface area for dissolution. Various techniques are used for solubility enhancement of poorly water soluble drugs. Formulation approaches include solubilization and particle size reduction techniques. Solid dispersions are more acceptable to patients than solubilization products, since they give rise to solid oral dosage forms instead of liquid as solubilization products usually do. Milling or micronization for particle size reduction is commonly performed as approaches to improve solubility, on the basis of the increase in surface area. Solid dispersions are more efficient than these particle size reduction techniques, since the latter have a particle size reduction limit around 2–5 mm which frequently is not enough to improve considerably the drug solubility or drug release in the small intestine and, consequently, to improve the bioavailability. Hence, solid dispersions prove a boon for the BCS Class II drugs as these results in enhancement of bioavailability
Full Text PDF