Background: Oxybutynin HCL is a muscarinic antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. Push-pull osmotic pump can be used for delivery of drugs having extremes of water solubility. Drug along with osmogents is present in the upper compartment whereas the lower compartment consists of polymeric osmotic agents.
Objective: Osmotic drug delivery system based on push-pull technique has been formulated in the form of bilayer tablets using wet granulation method. Method:The tablets were coated with semi permeable membrane of cellulose acetate followed by film coating. Precompressional parameters of matrix tablets
(bulk density, tapped density, Carr’s, index Hausner’s ratio, and angle of repose) are in the range of official standard, indicated that granules prepared. The post-compression parameters of extended release tablets (hardness, friability, weight variation, thickness, and drug content) were within the limits. The tablets were
evaluated physic-chemically.
Results: In FTIR study showed, there were no any interaction between the Oxybutynin HCl drug into HPMC, butylated hydroxyl toluene polymers, and into the all excipients at molecular level. The drug release pattern of final formulation was tested over the period of 18 h and it was found to be 81% which was comparable to that of reference product. The formulation F8 follows first-order release kinetics and the drug release mechanism was found to be non-Fickian anomalous diffusion. Oxybutynin release from the developed formulations was inversely proportional to the osmotic pressure of the release media, confirming osmotic pumping to be the major mechanism of drug release.
Conclusion: The optimized formulation was found stable at accelerated and long-term conditions.