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Overture of the sildenafil citrate gels and jellies: The simplified sight

Volume No : (2020) Volume: 08 Issue : 39 Year : 2020 Page No: 45-50

Authors : Mukul Kaushik, Saloni Bhatti

Abstract :

Erectile dysfunction (ED) is high occurring disease observed with aging and in patient with several risk factors such as heart disease, hypertension, obesity, diabetes, drug related, and pelvic surgery. Endothelial dysfunction is common factor underlying pathophysiology. Sildenafil is effective in large population of patients including difficult to treat population. Sildenafil (Viagra) is used to treat ED

(impotence; inability to get or keep an erection) in men. Sildenafil is used to improve the ability to exercise in adults with pulmonary arterial hypertension. The quality of life and satisfaction for treated men is well tolerated with considerable safety profile. Because sildenafil citrate is a treatment, not a cure, for ED, many men may choose to use it for an extended period. Sildenafil citrate also shows 

some side effects. The common side effects are headaches, feeling sick, hot flushes, indigestion, stuffy nose, etc., some of the serious side effects are chest pain. By preparing the fast-dissolving oral thin film of compositions, comprising bitter tasting sildenafil citrate and the bitter taste masking agent of sodium hydroxide, sodium bicarbonate or the mixtures there of, this invention provides a formulation of an excellent fast-dissolving oral thin film which can mask the bitter taste of sildenafil citrate and thus mitigating an unpleasant feelings at time of drug administration.

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