Volume No : (2020) Volume: 08 Issue : 38 Year : 2020 Page No: 32-38
Authors : Saloni Bhatti, Mukul Kaushik
Abstract :
Many drugs belong to BCS class-2 having poor solubility in water requires enhancement in solubility and dissolution rate for increasing its oral bioavailability; however, in many cases, immediate onset of action is required than conventional therapy. Tablet is the most popular among all dosage forms existing today because of its convenience of self-administration, compactness, and easy manufacturing, because of physiological changes associated with, especially elderly and pediatrics, are quite unable to swallow (dysphagia), rather this common problem of all age group patients. Solid dosage forms that can be disintegrated, dissolved, or suspended by saliva in the mouth resulting in easy swallowing, can provide significant benefits to the pediatric and geriatric population, as well as other patients who prefer the convenience of easily swallow able dosage forms. Mouth dissolving tablets (MDT) disintegrate instantaneously when placed on the tongue, releasing the drug that dissolves or disperses in the saliva. In MDT, superdisintegrants are incorporated in the right amount for quick disintegration with improved bioavailability. Based on the source, various types of superdisintegrants are available. They are synthetic, semi-synthetic, natural, and co-processed. In this review, the main emphasis is given on different types of natural superdisintegrants used in MDT, their mechanisms, and applications.
Keywords: Bioavailability, dispersible, dysphagia, natural, superdisintegrant
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