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Microemulsions: New vista in novel drug delivery system

Volume No : (2019) Volume: 07 Issue : 34 Year : 2019 Page No: 37-44

Authors : Lalita Chauhan, Prerna Thakur, Sheetal Sharma

Abstract :

Microemulsions are the novel drug delivery system for the treatment of several diseases. These are an isotropic, thermodynamically stable transparent system of oil, water, and surfactant. They have a long shelf life, better drug solubilization, ease of preparation, and administration in a potential drug delivery system. These versatile systems are clear, colloidal dispersion of water, oil stabilized by surfactant and cosurfactant and provides the protection against oxidation, enzymatic hydrolysis. Nowadays, microemulsion is widely used for hydrophilic as well as lipophilic drug delivery as drug carriers. They have numerous applications due to their unique properties such as ultralow interfacial tension, large interfacial tension, thermodynamic stability, and ability to solubilize other immiscible liquids. Microemulsions have great significance both in basic research and industry. In addition to the oral and intravenous route, they are suitable for sustained and targeted delivery through the ophthalmic, vaginal, dental, pulmonary, and topical route. The main objective of the study was to developing such a delivery system to minimize the drug degradation and loss, to prevent harmful side effects, and to increase the bioavailability. Therapeutic use of the microemulsion includes optimization of the duration of action decreasing the dosing frequency, controlling the site of release and maintaining the constant drug levels. Microemulsions have wide applications in terms of drug delivery. In this review article, we discuss the advantages, disadvantages, applications, preparation, theories, characterization, and significances of the microemulsion.

Keywords: Advantages, bioavailability, microemulsion, novel drug delivery system

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