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Drug utilization pattern in chronic kidney disease patients at a tertiary care teaching hospital

Volume No : (2019) Volume: 07 Issue : 34 Year : 2019 Page No: 31-36

Authors : Neeta J. Kanani, Vimesh R. Mistry, Sandeep J. Rathva

Abstract :

Background: Chronic kidney disease (CKD) patients receive many medications with multiple doses per day rendering them at high risk for developing drug-related problems.

Materials and Methods: A observational prospective study was carried out among the indoor patients of internal medicine wards and hemodialysis unit at Medical College Baroda and SSG Hospital, Vadodara, for 6 months. Patients of both sexes and of any age who were diagnosed to have chronic renal disease and on maintenance hemodialysis were included. Approval of IEC and informed consent was taken before initiation of the study. Data were analyzed using Microsoft Excel. 

Results: A total of 302 patient included in the study were analyzed, of which 185 were male and 117 were female with mean age of patient of 51.78 ± 8.93 years. Of these 302 patients, 17.88% of the patients were on maintenance hemodialysis and anemia was the most commonly occurring comorbid (95%) condition among them. Alimentary tract and metabolism class were the most commonly utilized class of drugs (41.87%) from anatomic therapeutic chemical classification and the average number of drugs prescribed was 9.35 ± 2.5. Drugs prescribed by generic name contributed to 64% of the lot and 76.6% from the national list of essential medicine. Fixed-dose drug combinations (FDCs) prescribed were 17.03%. Of total drugs prescribed, 84.91% of drugs were actually dispensed from the hospital drug store free of cost.

Conclusion: Variety of drug classes was prescribed in a cohort of CKD patients who contributing to polypharmacy and substantially increasing risk of drug interactions.

Keywords: Chronic kidney disease, drug utilization research, hemodialysis, polypharmacy

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