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Hydroalcoholic extract of Tribulus terrestris protects against accumulation of platinum in rat kidney

Volume No : (2019) Volume: 07 Issue : 33 Year : 2019 Page No: 7-14

Authors : Sharma US, Yadav HN, Singh S, Gupta YK

Abstract :

The present study has been designed to investigate the potential effects of the hydroalcoholic extract of Tribulus terrestris (TT) in cisplatin-induced nephrotoxicity and accumulation of platinum in kidney of Wistar rats. Pre-treatment of TT was started at a dose of 100/200/300 mg/kg oral once daily from day 1 to day 10. Nephrotoxicity was induced by administration of a single dose of cisplatin (8 mg/kg, i.p.) on the 7th day. Blood urea nitrogen (BUN), serum creatinine, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GPx) were measured. Renal histopathology, liver fatty acid binding protein (L-FAB), kidney injury molecule-1 (KIM-1), and platinum accumulation in kidney tissue were also determined by ICPMS. Single dose of cisplatin caused significant elevation of BUN, serum creatinine, MDA, KIM-1, L-FAB, and kidney platinum level, and fall in GSH, SOD, GPx, and histopathological changes in disease control as compared to normal control group (P < 0.001). Dose of TT 200 and 300 mg/kg significantly (P < 0.001) prevented abnormalities caused by cisplatin in the above parameters. The lower dose of TT 100 mg/kg did not show significant prevention as compared to the disease control group. TT 200 treated groups; platinum accumulation in kidney tissues was significantly different as the control group. TT exerted significant protection against nephrotoxicity induced by cisplatin and to a certain extent it decreases the level of accumulated platinum in kidney tissues; hence, TT could be beneficial in the prevention of cisplatin-induced nephrotoxicity followed by reactive oxygen species, inflammation, and oxidative stress.  

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