Aim: The aim of the present study was to formulate and evaluate the Transdermal Drug Delivery System of an antidiabetic herbal drug. And to increase the efficacy and to improve the patience compliance of the herbal medicine which can be achieved by developing alternative drug delivery system. Materials and Methods: The polymers that were used for selected sustained release of drug are HPMC E5 and polyethylene glycol used as a plasticizer. Transdermal patches of herbal extracts were prepared by solvent casting method. The patches were optimized on the basis of physicochemical evaluation such as thickness, folding endurance, physical appearance, uniformity of weight, moisture content and moisture uptake studies. The optimized formulations were further evaluated for the drug content, in vitro drug release, FESEM studies.
Results: The results of the study revealed that the herbal transdermal patch using the HPMC polymer showed the better physiochemical parameters such as thickness, folding endurance, physical appearance, uniformity of weight, moisture content and moisture uptake studies. The prepared formulations were found to be uniform with respect to thickness and folding endurance and showed the least moisture content and moisture uptake.
Conclusion: The patches prepared using the 30 % w/v of plasticizer showed the higher drug release from the herbal transdermal patch than the 20 and 25 % w/v during the in vitro studies in 24 hrs.