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Intravenous drug incompatibility in intensive care units - A  comprehensive review

Volume No : (2018) Volume: 06 Issue : 31 Year : 2018 Page No: 55-60

Authors : S. Sriram, S. Aishwarya, A. Ajith Kumar, Akhila Moithu, Akshaya Sebastian

Abstract :

In intensive care unit, intravenous (IV) therapy is preferred over oral therapy for a faster therapeutic  action. IV therapy is complex and error prone, requiring strategies to reduce the risk and complications.  Once injected, reversing the action is not possible unless an antidote exists. Drug incompatibility  results from the simultaneous dilution and/or administration of two or more drugs that interfere  with the therapeutic efficacy of the medications and patient safety, visually evidenced by the change  of solution color, precipitation, or turbidity. Incompatibility occurs  in vitro, which differentiates it  from real drug interactions that occur in vivo. Medication errors such as wrong drug, dose, diluents,  and cross-contamination errors with IV therapy further lead to death and harm to the patient. This  is a narrative review of physical and chemical IV drug incompatibilities and explores the preventive  strategies for the same. Findings from this review are useful in addressing current practice challenges

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