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Review Article
Year : 2014   |  Volume : 2  |  Issue : 4  |  Page : 470-485

A review on COX and their inhibitors: Present and future

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. These prostaglandins are also known as autocoid mediators that affect virtually all known physiological and pathological processes via their reversible interaction with G-protein coupled membrane receptors. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. The inflammatory molecule PGE2 lowers pain thresholds and the primary goal of oral inhibitors of PGE2 is to reduce pain. This review article provides an overview and an update on the progress achieved in the area of COX inhibitors and their role in health and disease conditions. It also discusses some unresolved issues related to the use of selective COX-2 inhibitors as a safe and promising therapeutic option not only for the treatment of inflammatory states but also for cancer and Alzheimer disease.
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