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Review Article
Year : 2014   |  Volume : 2   |  Issue : 4   |  Page : 408-413  

The prospective applications and challenges of calcium phosphate nanoparticles

Rakesh K Bijarnia

Correspondence Address:Department of Biochemistry, Panjab University Chandigarh, 160014, India

Source of Support: nil, Conflict of Interest: not declared


DOI: 10.4103/2231-4040.197331

Abstract  

The use of metal-based nanoparticles in biological system is associated with various well-known shortcomings. So, the role of inorganic calcium phosphate nanoparticles in drug delivery, imaging, bone and tooth augmentation and repair is increasing due to their bioactivity, biocompatibility, no immunogenicity and less toxicity. They are used as scaffold, cement, coating material and nanoparticles. However, their use as nanoparticles in drug delivery and imaging is appreciable in biological system. They are emerging as a second-generation non-viral vector for efficient delivery and stabilization of nucleic acids. The current appraisal is an update about the recent advancements in drug delivery, imaging, orthopedic and dental fields. The review will also discuss about the shortcomings and related strategies to overcome the problems with calcium phosphate particles.

Keywords: Calcium phosphate nanoparticles, Drug delivery, Nanoparticle toxicity

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