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Year : 2018   |  Volume : 6  |  Issue : 1  |  Page : 13-16



Transdermal drug delivery by iontophoresis: Mechanistic aspects
The passive diffusion of drugs in transdermal delivery is hindered by the stratum corneum and limits the scope of deliverable molecules through the skin. The evolution of novel electrical and physical enhancement techniques can enable the delivery of hydrophilic and larger molecules such as proteins and peptides through the skin. Iontophoresis utilizes small amounts of direct current to push charged drug molecules through and across the skin. Several drug categories have been investigated over the years as possible drug candidates for this mode of delivery. It enables the delivery of more hydrophilic molecules in contrast to conventional transdermal delivery and has an advantage of modulating the rate of delivery by changing the electrical parameters.
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